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Make You a Priority — Including Your Sex Life
What is bremelanotide?
Bremelanotide, also known as PT-141, is a peptide treatment made for premenopausal women with low sex drive and desire. Many women also say they feel more sexually aroused after using it.
Bremelanotide can also boost sexual arousal and improve erections in men. It may help men with low sex drive or arousal issues have stronger, more natural-feeling erections.
Know the Difference:
🔥 Sex Drive (Libido):
This is your body’s natural urge or motivation for sex—kind of like hunger, but for intimacy. It’s influenced by things like hormones, sleep, stress, and overall health.
🟢 Example: You feel like you want sex, even if nothing specific is happening to trigger it.
💭 Sexual Desire:
This is more mental and emotional—it’s about how much you feel like being intimate, often in response to thoughts, feelings, or a connection with someone.
🟢 Example: You’re enjoying time with your partner and start to want intimacy.
⚡ Arousal:
This is your body’s physical response to sexual stimuli. It can happen with or without desire, and includes things like increased heart rate, lubrication, or genital sensitivity.
🟢 Example: You’re being touched or stimulated and your body responds, even if you didn’t feel “in the mood” at first.
How does bremelanotide work?
Bremelanotide is a type of peptide that works by activating something called melanocortin receptors. Melanocortin is a natural hormone in your body that affects the brain and nervous system to help trigger sexual arousal and behavior. Scientists aren’t exactly sure how it boosts sex drive, but it’s believed to work through these brain pathways. It can also affect the cells that control skin color, called melanocytes.
What are the benefits of bremelanotide?
- Increased sex drive
- Increased sexual desire
- Increased sexual arousal
- Decreased stress related to low sex drive
- Improved erections
Who Shouldn’t Take Bremelanotide?
- Individuals with high blood pressure that is not controlled (uncontrolled hypertension)
- Individuals with known heart disease
- Adolescents and children under 18 years
- Anyone who is pregnant, may become pregnant, or is breastfeeding
- Individuals taking naltrexone for alcohol/opioid addiction or weight loss
This treatment isn’t for low sex drive caused by health problems (e.g., MS, diabetes, heart disease, kidney disease), relationship issues, or side effects from other medications or drugs (e.g., antidepressants).
What are the common side effects of bremelanotide?
The following side effects may get better over time as your body gets used to the medication:
- Nausea
- Flushing of the skin
- Injection site reactions (e.g., pain, redness, bruising, itching)
- Headache
The following side effects aren’t common but have also been reported:
- Tiredness
- Dizziness
- Hot flush
- Temporary increase in blood pressure and slower heart rate may happen shortly after using bremelanotide, but usually go away within 12 hours.
- Skin darkening may happen on the face, gums, or breasts—this is more common in people with darker skin tones.
How do I take bremelanotide?
Bremelanotide should be injected into the fatty tissue (subcutaneous injection) of your upper legs or lower stomach. The injections can be done at home.
What is the typical bremelanotide dosing?
Most people start with a 1 mg injection, taken under the skin about 45 minutes before sexual activity. Depending on how you respond, your healthcare provider may adjust the dose—up to a maximum of 2 mg per use. Since everyone’s body reacts differently, finding the dose that works best for you might take a little time.
Bremelanotide is only taken when needed, 45 minutes before sexual activity. It’s not meant for daily use.
- Do not inject more than 1 dose of bremelanotide within 24 hours of your last dose,
- Do not inject more than 3 doses of bremelanotide in one week.
- Do not inject more than 8 doses of bremelanotide within one month.
FREQUENTLY ASKED QUESTIONS ABOUT BREMELANOTIDE
How does bremelanotide make you feel?
Bremelanotide may help increase your interest in sex and make you feel more mentally and physically aroused. Some people also report feeling more connected or in the mood after using it.
I am worried about side effects. What should I expect?
Common side effects include nausea, flushing (warmth or redness in the face), headache, and injection site reactions. Most side effects are mild and go away on their own.
Most people experience nausea after the first bremelanotide dose, but it can happen with any injection. It usually lasts about 2 hours and goes away on its own — and often improves with the second dose.
How long does it take bremelanotide to start working?
It’s not exactly known how quickly bremelanotide works after each dose. Most people begin to feel the effects after about 1 hour, though it can vary slightly from person to person. Everyone’s body is different, so it may take less time for you to feel a change.
How long does bremelanotide last?
Bremelanotide usually works for several hours, but how long it lasts can depend on how your body reacts. The medicine stays in your system for about 12 to 14 hours, though it works best in the first few hours after you take it. Since everyone is different, you might need to adjust when you take it based on how it works for you.
How long before sex should you use bremelanotide?
You should inject bremelanotide at least 45 minutes before sex. Since everyone’s body and sex drive are different, it may work at slightly different times for each person. You can adjust the timing based on how it works for you and if you have any side effects after your first dose.
Does bremelanotide cause weight gain?
People who took bremelanotide in clinical studies did not report weight gain as a side effect.
Why is bremelanotide limited to 1 dose every 24 hours, with a maximum of 3 doses per week and no more than 8 doses per month?
Taking more than the recommended amount of bremelanotide can increase the risk of side effects like high blood pressure, low heart rate, and skin discoloration.
Does bremelanotide affect hormone levels?
No, bremelanotide doesn’t directly change hormone levels like estrogen or testosterone. Instead, it works in the brain by activating melanocortin receptors, which influence sexual desire and arousal. It helps improve the brain’s response to sexual cues without altering hormone production.
Can bremelanotide be used in postmenopausal women?
Some women who have gone through menopause might find bremelanotide helpful, but their low sex drive is often linked to changes in hormones. Bremelanotide doesn’t treat those hormone changes. So far, studies have only looked at how it works in women who haven’t gone through menopause. More research is needed to know if it works well for postmenopausal women too.
Do I have to avoid alcohol with bremelanotide?
No. It’s okay to drink alcohol with bremelanotide.
Where should I store bremelanotide?
Bremelanotide should be stored in the refrigerator.